Journal article
Alteration to hippocampal volume and shape confined to cannabis dependence: a multi-site study
Y Chye, V Lorenzetti, C Suo, A Batalla, J Cousijn, AE Goudriaan, M Jenkinson, R Martin-Santos, S Whittle, M Yücel, N Solowij
Addiction Biology | WILEY | Published : 2019
DOI: 10.1111/adb.12652
Abstract
Cannabis use is highly prevalent and often considered to be relatively harmless. Nonetheless, a subset of regular cannabis users may develop dependence, experiencing poorer quality of life and greater mental health problems relative to non-dependent users. The neuroanatomy characterizing cannabis use versus dependence is poorly understood. We aimed to delineate the contributing role of cannabis use and dependence on morphology of the hippocampus, one of the most consistently altered brain regions in cannabis users, in a large multi-site dataset aggregated across four research sites. We compared hippocampal volume and vertex-level hippocampal shape differences (1) between 121 non-using contro..
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Awarded by Schizophrenia Research Institute
Funding Acknowledgements
Original data collection was supported by the Netherlands Organization for Scientific Research-Health Research and Development, ZON-Mw (A. G., grant #31180002); an Amsterdam Brain Imaging Platform grant (J. C.); Plan Nacional sobre Drogas. Ministerio de Sanidad y Politica Social (R. M. S., grant PNSD:2011/050 and SGR:2014/1114); the Clive and Vera Ramaciotti Foundation for Biomedical Research (N. S.); the Schizophrenia Research Institute with NSW Health (N. S.); and the National Health and Medical Research Council (NHMRC) of Australia (N. S., Project Grant #459111).